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We and others previously demonstrated GDF8 and ActA are the two major ligands which mediate the muscle minimization actions of the ActRIIA/B receptors in non-obese mice and NHPs 22,28,30 , and we have further shown that dual blockade of GDF8 and ActA led to much larger increases in muscle mass than blocking either ligand individually, and that dual blockade matched the muscle growth actions of broader ActRIIA/B blockade 28 , similar to effects seen when using a dominant-negative type II receptor or pro-domains of GDF8 and activins 22,26,27

When comparing semaglutide specifically against other diabetes and obesity drugs including Farxiga, metformin, and orlistat the reseachers again saw a higher rate of suicidal ideation reported for semaglutide, according to the study, published Tuesday in JAMA Network Open

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A pilot study