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When assessing baseline characteristics by comparator (Additional file 4: Appendix Table S4C), the proportion of subjects with heart failure, other prior CV events and prior insulin use was higher, and mean eGFR was lower, in the placebo and semaglutide groups than in the other comparator groups, driven by the large patient numbers and high baseline CV risk in the CVOTs
Thinking about moving from injections to tablets
GLP-1RAs, as an important class of drugs for the treatment of T2DM, shows significant advantages in blood glucose control, weight loss, cardiovascular protection and kidney benefit (Ussher and Drucker, 2023
In the analysis that most closely reflects real-world clinical practice, participants taking oral semaglutide lost an average of 13.6% of their starting body weight, compared with just 2.4% in those receiving placebo
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