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This surge may be attributed to the FDA mandating manufacturers of incretin-based medications to revise their product labels in 2009, providing information regarding the potential risk of pancreatitis (Nelson et al., 2014)
184,185,186,187 Interactions with other pathways GLP-1 not only promotes the release of insulin but also enhances the response of pancreatic -cells to insulin through the PI3K/Akt pathway, thereby improving insulin signal transduction and increasing the sensitivity of peripheral tissues to insulin
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