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Wambogo, E., et al

Zepbound received approval in November 2023 for chronic weight management in adults with obesity or overweight plus a weight-related condition, and in December 2024 for moderate-to-severe obstructive sleep apnea in adults with obesity

This structural mismatch between BPC-157s biology and standard drug development pathways has contributed to the slow pace of clinical trial development, though it has not diminished scientific interest in the compound

Iron overload caused cardiac mitochondrial dysfunction, as indicated by increased ROS production, mitochondrial membrane depolarization and mitochondrial swelling, and only the mitochondrial calcium uniporter completely protects against the cardiac mitochondrial dysfunction caused by iron overload