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Like GIP, GLP-1 is released in response to ingestion of nutrients and acts on pancreatic cells to stimulate insulin secretion
Divide the dose 60/40 or 50/50 between morning (fasted) and evening (at least 2 hours after eating)
Its defining trait in the research literature is selectivity: unlike older GHRPs such as GHRP-6 or GHRP-2, ipamorelin is reported to release GH without meaningfully raising cortisol, prolactin, ACTH, or aldosterone, and with only minimal appetite stimulation
A more recent Phase 2 trial 14 with low-dose semaglutide showed reductions in laboratory-based alcohol self-administration and craving scores, with some effect sizes exceeding Cohens D of 0.80
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