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In a randomized placebo-controlled trial that included 101 participants with fibromyalgia, those who received 3 mg or 5 mg of melatonin nightly in addition to antidepressant therapy with fluoxetine had improvement on Fibromyalgia Impact Questionnaire scores after eight weeks
Pan Y, Luo RZ, Peng H, Bao J, Hu W, Andreeff M , Issa JP, Bast RC, Yu Y
[3] In various cellular processes, NAD+-dependent/-consuming enzymes modify proteins post-translationally using NAD+ and its other forms as substrates
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