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Celecoxib treatment resulted in a 45% reduction in mammary PGE2 levels and attenuated mast cell influx and angiogenesis, suggesting that COX-2-selective inhibitors may be useful in the prevention or treatment of breast cancer associated with elevated human IGF-1 levels (110)

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PMID: 29668112 A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors