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"The biggest benefit is reducing the food noise
Given the lack of individual preclinical models of PCOS that recapitulate all the metabolic, endocrine, and gonadal traits of the clinical syndrome, pharmacological testing was conducted in parallel in these two PCOS models, which are among the most reliable to mimic the metabolic and gonadal phenotype of women with PCOS 36,37 , capturing also the heterogeneity of this condition 38
Sanyal A, Charles ED, Neuschwander-Tetri BA et al (2019) Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial
Further studies are also needed on TZPs effects across diverse populations, including different ethnicities and ages, as well as those with related conditions such as heart failure with preserved ejection fraction or non-alcoholic steatohepatitis, where preliminary data suggest potential benefit
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