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174 Accumulated ceramide mediates the activation of protein phosphatase 2 A (PP2A) and impairs insulin-dependent activation, in addition to signaling of PI3K/Akt by PKC, 175 thereby also disrupting lipid metabolism by inhibiting oxidation and stimulating fatty acid uptake
Ozempic is FDA-approved for type 2 diabetes treatment but may be prescribed off-label for weight loss at a healthcare providers discretion
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