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Xue et al., 2004
Results While GLP-1 and GIP agonists demonstrate significant metabolic benefits, their long-term use is often limited by gastrointestinal side effects and psychological impacts
Even intravenous administration of GLP-1 at a physiological postprandial dose of 0.3 pmol/kg/min significantly slowed the rate of gastric emptying in healthy subjects, bringing them into a state of gastroparesis (Little et al., 2006)
Kidney Disorders : Patients with impaired kidney function may require close monitoring since the medicine's metabolism and excretion could be affected
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