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Without adequate B12, homocysteine levels rise, and elevated homocysteine is neurotoxic, potentially causing direct damage to nerve cells and blood vessels that supply nerves
Individuals who might theoretically be candidates for both treatments could include: Men with obesity and hypogonadism , where weight loss is a clinical priority alongside hormone replacement Transgender men on testosterone therapy who also have obesity-related metabolic conditions Individuals enrolled in clinical trials investigating retatrutide's effects on metabolic syndrome, where testosterone use is a pre-existing condition It is important to note that combining an unlicensed investigational drug with a licensed hormone therapy requires careful oversight
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