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[6] As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1GLV, PDB: 1GSA, PDB: 1GSH, PDB: 1M0T, PDB: 1M0W, PDB: 2GLT, and PDB: 2HGS
The cycle structure exists for a practical reason: continuous stimulation of the same receptor pathways can lead to reduced sensitivity over time, and a rest period allows the system to reset before the next cycle produces full effect
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