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"Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes." New England Journal of Medicine , 385(6), 503-515
Functionally, no-DAC CJC-1295 acts like a somewhat longer-lasting GHRH signal: it binds the pituitary GHRH receptor, a G-protein-coupled receptor that raises intracellular cyclic AMP in somatotroph cells, and pushes those cells to synthesize and release GH but only for a window measured in minutes to a couple of hours, not days
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