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Post-translational modifications, including deamidation, oxidation, glycosylation , and other chemical changes, can significantly alter a proteins charge profile, directly impacting its safety, efficacy, pharmacokinetics , and immunogenicity
This gene variation negatively impacts carnitine transport across the blood-brain barrier (in males and not females), preventing the synthesis of a carnitine precursor called trimethyllysine
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doi: 10.1158/0008-5472.CAN-07-5003 85 YangHMagilnickNLeeCKalmazDOuXChanJYet al
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