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Mechanisms and strategies for combating cancer drug response and resistance Altered drug transport and metabolism One of the central barriers to effective chemotherapy is the development of MDR, wherein tumor cells acquire cross-resistance to structurally and mechanistically distinct agents (Fig

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[2] It's worth noting that most people should aim to meet their magnesium requirements primarily through dietary sources

Benzodiazepines and Z-drugs suppress cortical activity broadly, knocking you unconscious but actually reducing deep sleep