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doi: 10.1155/2017/9719647 138 RamanKGSappingtonPLYangRLevyRMPrinceJMLiuSet al
And direct GLP-1 receptor activation in neurons appears to modulate microglial activity, dampening the chronic immune response that underlies much late-life cognitive decline
emerging evidence suggests they may offer psychiatric benefits: reduced binge-eating impulses, decreased substance cravings, and potentially improved mood independent of weight loss
In STEP-1 (N=1,961), semaglutide 2.4 mg produced 14.9% mean body weight loss at 68 weeks versus 2.4% with placebo, and the lipid improvements tracked closely with this weight reduction 1
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