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This finding is consistent with the results of the SURPASS clinical trial program and a meta-analysis of the SURPASS trials which found a similar incidence of hypoglycemia with tirzepatide versus placebo and a low incidence of severe hypoglycemia [14,15,16,17,18,19,20]
For semaglutide (Wegovy), treatment should be discontinued at least two months before a planned pregnancy, while liraglutide (Saxenda) should be stopped before pregnancy (with no specific lead time stated in the SmPC)
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Jumping from 0.25 mg directly to 1 mg, which can happen with a single concentration mix-up, commonly causes severe nausea, vomiting, and in some cases, serious gastrointestinal distress
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