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The efficacy and safety of oral semaglutide for glycaemic management in adults with type 2 diabetes compared to subcutaneous semaglutide, placebo, and other GLP-1 RA comparators: a systematic review and network meta-analysis

Combining these effects with severe caloric restriction could exacerbate gastrointestinal distress and increase the risk of dehydration

Semaglutide showed improvements in diabetes and body weight, as well as a reduction in the rate of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes, who are at high risk of cardiovascular disease

Most of the time, if constipation is dangerous, it's because it's a symptom of an underlying disease like a bowel obstruction, a problem with pelvic muscles, nerve damage, or IBS