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As the name suggests, this is a form of cell death caused by copper, in which copper ions directly bind to protein lipoylation components in the tricarboxylic acid circulation pathway, causing abnormal aggregation of lipoylated proteins and loss of iron-sulfur cluster protein, resulting in protein toxic stress responses and cell death (172)

The antioxidant activity of fangchinoline and cepharanthine was reported from Stephania rotunda by in vitro assays (Glin et al., 2010)

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10.1021/acs.jafc.3c05305 154 QianW.HengyeC.ZhejuanL.ShuyiL.BeiH.YanQingG.et al (2013)