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TGR5-deficient mice have increased colonic mucosal permeability, through disruption of epithelial tight junctions (176)
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Promote proliferation and differentiation of osteoblasts, accelerate bone formation Activate key signaling pathways in osteoblasts Wnt/ - catenin pathway: AOD 9604 upregulates Wnt3a expression, activates - catenin nuclear translocation, promotes osteoblast proliferation and differentiation, and enhances osteoblast quantity and activity
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