We dont know how the prices of novel GLP-1s will change, we dont know what new GLP-1s will be introduced, we dont know how many generics there will be, we dont know how many people will ultimately use them, we dont know how long people will stay on them, we dont know what Medicare drug price negotiations will do to the price, and we dont even know if reducing obesity impacts long-term health spending
While all GLP-1RAs activate the same receptor, they differ in their structures (e.g., semaglutide has 94% homology to native GLP-1 with specific amino acid substitutions and fatty acid side chain allowing albumin binding) and half-life (~ 1 week for semaglutide, five days for dulaglutide, and 13 hours for liraglutide)
Clinically meaningful appetite suppression and weight loss typically dont appear until 1.0 mg or higher
McEwens studies show that the compound actually works on the genetic level, stimulating genes to produce a molecule that prevents excessive firing of nerve cells in key mood areas