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It is naturally produced by the body from two amino acids (lysine and methionine) in the liver and kidneys

Patients experiencing persistent vomiting, severe abdominal pain, or signs of pancreatitis should seek immediate medical attention

However, meaningful, clinically significant weight loss typically defined as 5% of baseline body weight, a threshold referenced in NICE guidance on the management of overweight and obesity generally becomes apparent between weeks 8 and 12 , particularly as the dose is gradually escalated according to the trial protocol

Risk of Gastrointestinal Adverse Events with GLP-1 Receptor Agonists for Weight Loss