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The changes due to VLCAD were subtle in effect.[ref] Other studies in people with long-chain fatty acid oxidation disorders also show a modest increase in inflammatory cytokine levels, including during exercise challenges.[ref] Heart impacts: People with VLCADD are at a higher risk of heart problems, such as cardiomyopathy

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The honest conclusion is that the GLP-1 neurodegeneration thesis has been substantially weakened, not by one trial but by a consistent pattern across two diseases and several molecules