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Retatrutide is administered as a once-weekly subcutaneous injection, similar in delivery to other peptide-based obesity treatments currently available
A sensitized high-throughput screen identified a series of small molecule GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nM potency
The rest of authors declare not to have any conflicts of interest that may be considered to influence directly or indirectly the content of the manuscript
Not only have the molecules remained on the market, utilization is increasing, suggesting that some pharmacies may be leveraging formulation additives or alternative delivery mechanisms to justify continued production
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