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A GLP1 prescription could indicate: Well-controlled type 2 diabetes Severe obesity under active treatment Metabolic dysfunction associated steatohepatitis (MASH) Obstructive sleep apnea Elevated cardiovascular risk Chronic kidney disease Clinically, those are very different scenarios with very different mortality implications

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108 Overall, these studies suggest that although weight loss from dietary restriction can compromise skeletal health, incorporating exerciseparticularly endurance trainingcan preserve BMD and hormonal factors, and reduce bone resorption, thereby offering partial protection to the skeleton during obesity treatment

Chang KS, Fan YH, Andreeff M , Liu J, Mu ZM