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The Ozempic prescribing information lists three indications, all in type 2 diabetes: glycemic control, reduction of major adverse cardiovascular event risk in adults with established cardiovascular disease, and reduction of the risk of sustained eGFR decline, end-stage kidney disease and cardiovascular death in adults with chronic kidney disease

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Losing weight often involves losing some muscle along with fat, and since muscle burns more calories than fat, your daily energy expenditure drops further