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GIP receptor agonism amplifies insulin response, may reduce nausea at higher doses (a counterintuitive but documented effect), and appears to enhance the metabolic effects of GLP-1 agonism synergistically
"Tirzepatide effectively reduced drive to eat, as well as food-cue-driven and other-cue-driven eating behavior." Nature Medicine This effect is due to tirzepatides action on both GIP and GLP-1 receptors, which slows gastric emptying, signals fullness to the brain, and improves insulin sensitivity
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