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They regulate local intestinal function and systemic metabolism through multiple mechanisms (77)
While there is no major red flag interaction that prevents the two from being used together, there are several biological factorssuch as digestive speed and kidney healththat you should consider
Unlike endogenous GLP-1, which is rapidly degraded by dipeptidyl peptidase-4, GLP-1 receptor agonists are resistant to degradation and have longer half-lives, particularly for modern long-acting agents, such as liraglutide, dulaglutide, semaglutide and tirzepatide
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