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The Endocrine Society recommends initiating or up-titrating an alternative agent (metformin, SGLT2 inhibitor, or basal insulin) at the start of the taper rather than after the last dose [6]
This biological pushback explains why standard diet and exercise programs routinely stall after the initial few months
As interest grows in utilizing GLP-1RAs as an adjunct therapy for patients experiencing WR or as a preventive measure post-surgery, further research is essential to elucidate their role and establish evidence-based guidelines for effective use in this population
Blood 91: 3817-3824.CrossRefGoogle Scholar MURRAY, R.K., GRANNER, D.K., MAYES, P.A
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