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J Pharmacol Exp Ther 311:99108 Clancy RM, Levartovsky D, Leszczynska-Piziak J, Yegudin J, Abramson SB (1994) Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary
ROS also induce lysosomal membrane permeability, resulting in the release of cathepsin D and caspase-8, which can further activate Bid and amplify CRT exposure [151, 152]
Together, these peptides are studied in controlled experimental environments to better characterize how multi-peptide formulations may influence coordinated cellular signaling, molecular pathway interaction, and system-level biological responses under laboratory conditions
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