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However, DPRA is not suitable for metallic compounds, because they may form bonds with the nucleophilic residues in histidine 20

Preliminary antitumoral activity has been presented at ASCO 2024, with an ORR of 19% and a median DoR of 11.3 months in all NSCLC subtypes (n=116) and 31% and 11.6 months, respectively, in non-squamous taxane-nave NSCLC (n=42)