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There is evidence of bromodomain inhibitors being successful in reducing heart failure admissions in diabetic patients comorbid with acute coronary syndrome (136)

In heterodimeric GST complexes such as those formed by the cytosolic mu and alpha classes, however, the cleft between the two subunits is home to an additional high-affinity nonsubstrate xenobiotic binding site, which may account for the enzymes' ability to form heterodimers

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