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Removal of the N-terminal amino acids of chemokines significantly alters receptor selectivity
GLP-1s also activate receptors in the hypothalamus area of the brain (the control center for hunger and thirst) to curb appetite
Topical NSAIDs such as diclofenac 1% gel (Voltaren, available over-the-counter in the US) can provide localized pain relief for musculoskeletal conditions with minimal systemic absorption and reduced gastrointestinal risk
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