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Moreover, the R17 Cagri- E14 Cagri ionic lock was present in the bypass conformation but absent in the CT-like conformation in both CagriBB-bound structures, consistent with a higher energy requirement to form the CT-like conformation (Supplementary Fig

The difference between strains was already evident at 72 h and persisted until 15 days post injection, a time point when DA Gsta4 animals displayed minimal visible demyelinating damage, whereas such damage was still readily evident in the DA Wt strain

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