It is not the same as walking into a medical office and receiving an established, FDA-approved obesity medication
When that fat under the skin shrinks rapidly, the dermis and epidermis may not bounce back at the same rate, so skin becomes saggy, wrinkled, or sunken, especially around the cheeks, jawline, and neck
Eli Lilly solved this problem by fine-tuning the receptor affinity ratios so GLP-1 activity dominates during the critical feeding window, preventing the glucose elevation that killed previous candidates
Molecules 26:6444 Snchez-Tapia M, Miller AW, Granados-Portillo O, Tovar AR, Torres N (2020) The development of metabolic endotoxemia is dependent on the type of sweetener and the presence of saturated fat in the diet