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N-Acetyl-Cysteine (NAC) This antioxidant is both insulin sensitizing and anti-inflammatory

Before reaching the target dose, a typical dosing schedule may look like the following: Month 1: 0.25 mg once weekly for the first month Month 2: 0.5 mg once weekly for the second month Month 3: 1 mg once weekly for the third month Month 4: 1.7 mg once weekly for the fourth month Target maintenance dose: 2.4 mg once weekly Depending on whether or not there are any experienced side-effects may change the dosing schedule for some individuals

Whether or not people can successfully de-escalate could be related in part to how they metabolize the drug and the length of that steady state, Pinto says

Aronne LJS, Horn N, He DBB, et al