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Pre-existing risk factors for gallstone disease include: Female sex : Women are two to three times more likely to develop gallstones than men, particularly during reproductive years due to hormonal influences Age over 40 years : Gallstone prevalence increases progressively with age Obesity : Higher body mass index correlates with increased gallstone risk, creating a paradox where the condition being treated is itself a risk factor Rapid weight loss history : Previous episodes of quick weight reduction may indicate susceptibility Pregnancy or recent pregnancy : Hormonal changes affect bile composition and gallbladder motility Family history : Genetic factors contribute to gallstone formation Certain ethnicities : Native American and Hispanic populations have higher gallstone prevalence Metabolic syndrome and diabetes : These conditions are associated with altered bile metabolism The rate and magnitude of weight loss during semaglutide treatment significantly influence gallbladder complication risk

SPL UNCLASSIFIED SECTION Gastrointestinal Adverse Reactions In a pool of Study 1 and 2, gastrointestinal adverse reactions occurred more frequently among patients receiving ZEPBOUND (5 mg 56%, 10 mg 56%, 15 mg 56%) than placebo (30%)

It activates one receptor