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Parvalbumin-positive interneurons in the cortex and hippocampus are believed to have a key role in cognition and other higher brain functions, 32, 33, 34 and these neurons are particularly sensitive to oxidative stress

They can be used to treat problems such as joint pain, arthritis, sciatica and inflammatory bowel disease

The relevant caution from the paper's own discussion is that FOXO4 has a normal role in DNA-damage repair and Foxo4-knockout mice handle acute damage badly, which is why the authors explicitly ruled out permanent FOXO4 inhibition

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