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AstraZenecas GLP-1 pill significantly and meaningfully reduced weight and blood sugar levels in a pair of mid-stage studiesbut not enough to sufficiently outperform a key competitor from Structure Therapeutics

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A 2019 systematic review by Dilokthornsakul and colleagues in the Journal of Cosmetic Dermatology searched five databases through October 2017 and included four clinical studies (three placebo-controlled RCTs and one single-arm trial) evaluating oral glutathione 250-500 mg/day and topical 2% oxidized glutathione, concluding that evidence for skin-whitening effects remained inconclusive due to inconsistent findings across trials and the limited bioavailability of oral GSH with no significant effect observed in sun-protected skin areas