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The medication is used in adults with a body mass index of 30 or more, or from a BMI of 27 if at least one comorbidity such as type 2 diabetes, dyslipidemia, or controlled high blood pressure is also present
Both of these conundrums can be explained by a model where IMiDs behave as a switch to block ubiquitination of natural substrates of CRL4 CRBN , but promote ubiquitination of neo-substrates, such as IKZF1 and IKZF3 (Figure 4B)
2007;292(6):G1770-83
For patients already on hormone replacement therapy (HRT), the notion of reducing senescent cell load may complement hormone optimisation by reducing the age burden on the tissues
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