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Protect cells from damage
We conducted a safety evaluation of the candidate compounds, followed by an assessment of their therapeutic effects in APP/PS1 transgenic mice
Individual NTHi strains are capable of producing up to four different haemoglobin/haemoglobin-haptoglobin binding proteins (Hgp) that collectively display affinity for all known human haptoglobin phenotypes (Morton et al., 2006)
FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis
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