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The recognition of LPS by TLR-4, induces also platelet secretion of IL-1 through the NF-kB pathway, increasing the activation of endothelial cells and leading to vascular inflammation
In terms of change in body weight versus other oral glucose-lowering agents (those described above), the GLP-1RAs show relatively consistent improvement, that is, reduction, either as monotherapy or add-on treatment (
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