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GLP-1 receptor knockout and GIP receptor knockout mice for mechanism delineation Receptor binding studies: Human, mouse, and rat receptor-expressing cell lines In vitro systems: Primary hepatocytes for gluconeogenesis studies
They serve different clinical purposes and cannot substitute for each other
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Some orthopedic surgeons may perceive the growing use of GLP-1 receptor agonists as a potential threat to their practice, fearing that widespread weight loss could reduce the volume of patients requiring joint replacements
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