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Coupled with endogenous reactive oxygen species (ROS) generated as by-products of various cellular processes, strict regulation of antioxidants is critical to maintaining a balanced reduction/oxidation (redox) state
Oxidative cell death in cancer: mechanisms and therapeutic opportunities, Cell Death & Disease 2024 15:8 , vol
PMID: 42176271 Cell Rep 2024 Aug 7;43(8):114591
In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022
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