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Clinical data hasnt definitively proven a direct chemical link between the medication and depressive symptoms
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GLP-1 receptors are expressed in the enteric nervous system and in the vagus nerve ( Glp1r mRNA expression, immunofluorescence analyses in Glp1r.tdTomato reporter mice reveal GLP-1R expression in various enteroendocrine cells (Table 1), but not GLP-1+ cells ( Glp1r expression to be within the epithelial fraction instead of crypt, mesenchyme, or smooth muscle layer fractions (Yusta et al., 2015)
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