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Additionally, the nuclear export signal (NES) in KEAP1 has been shown to be important for NRF2 regulation, as it was found to facilitate the transport of the NRF2-KEAP1 complex out of the nucleus, which terminates NRF2-mediated antioxidant signaling after stress [16]
Balanced nutrition plays a critical role
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Moreover, the suppression of fat intake from systemic OEA is prevented when a mixed dopamine 1 receptor (D1R) and dopamine 2 receptor (D2R) antagonist is infused into the dorsal striatum [104]
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