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Suspected adverse reactions to any unlicensed compound should be reported to the MHRA via the Yellow Card Scheme at yellowcard.mhra.gov.uk

In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)

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Therapeutic strategies to reduce TMAO levels are being studied including antibiotics and targeted molecules [11, 12]