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If an adverse effect, or even the inconvenience, of a particular therapy outweighs the benefits for the patient, then it might not be worthwhile to include it in a management strategy
Therefore, developing a comprehensive therapeutic platform capable of spatiotemporal ROS scavenging, regulation of macrophage polarization, and enhancement of angiogenesis and cell proliferation represents a critical research focus for improving clinical outcomes in chronic diabetic wound management
Because there have been no large-scale human clinical trials, the full range of short-term and long-term side effects is unknown
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