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In experimental models, it is used to investigate melanocortin mediated CNS pathways and downstream signaling, with a mechanistic focus distinct from direct peripheral vasodilatory (blood flow) mechanisms
(1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature 385(6612):165168
Weight loss is 12.4% in trials (vs 15-22% for injectables), but self-pay pricing is significantly lower ($149-$349/month vs $1,000+/month for injectables)
Its a common occurrence in people with diabetes
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