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In the triple therapy cohort receiving metformin, SGLT2-i, and GLP-1RA, overbasalization declined from 62.5 to 17.5%, and 42.5% of patients were able to stop insulin entirely, reinforcing the additive benefits of combination therapy [44]
Not all rectal bleeding is dangerous, but it should never be ignored
The human research is early but the preclinical literature is deep and consistent
Clinical trials have demonstrated that most gastrointestinal symptoms are mild to moderate in severity and resolve within several weeks of maintaining a stable dose
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